ABSTRACT
Objective Toevaluatetheefficacyofneoadjuvantchemotherapy(NACT)forlocallyadvancedcervicalcancer(LACC) byusinghighresolutionRESOLVE DWIsequence..Methods 34patientswithLACCconfirmedbypathologyunderwentroutine plainandenhancementMRscanandRESOLVE DWIscan withbvalueof0 mm2/s,1000 mm2/sbeforeNACT,afterthefirst chemotherapy(2.5weekslater)andthesecondchemotherapy(5weekslater).TheADCvaluewascalculated.Thetumorvolumewas calculatedusingtumorsegmentationsoftware.Therateoftumorwithdrawalwascalculatedinthemiddle(2.5weeksafterthefirst chemotherapy)andlatestages(2.5weeksafterthesecondchemotherapy),whichwerejudgedaccordingtotheRECIST1.1standard. Results In29patientsofeffectivetreatment,theADCvaluesoftheLACCsignificantlyincreasedfrompre-chemotherapy[(0.887± 0.14)×10-3 mm2/s]toafterthefirstchemotherapy [(0.974±0.12)×10-3 mm2/s]andsecondchemotherapy [(1.023±0.17)× 10-3 mm2/s](t=2.403 ,P<0.05;t=3.397,P<0.05).Theratesoftumorwithdrawalsignificantlyincreasedfromthefirstchemotherapy (58.21%±20%)tothesecondchemotherapy(77.60%±12%)(t=4.297,P<0.05)I.n5casesofineffectivetreatment,theADCvaluesofthe LACCshowedadownwardtrendfrompre-chemotherapy[(0.867±0.06)×10-3 mm2/s]toafterthefirstchemotherapy[(0.848±0.16 )× 10-3 mm2/s]andsecondchemotherapy [(0.842±0.15)×10-3 mm2/s](t=0.934,P=0.378;t=0.886,P=0.401).Theratesof tumorwithdrawalshowedadownwardtrendfromthefirstchemotherapy(14.14%±15%)tothesecondchemotherapy(-21.22%±13%) (t=1.003,P=0.345).Conclusion TheADCvalueofRESOLVEDWIandtherateoftumorwithdrawalmaybeusedtoevaluatethe efficacyofNACTforthepatientswithLACC,whichwouldhavegoodclinicalpracticalvalue.